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The Science

Seanol® is made up of 8 interconnected polyphenolic rings giving it 10 to 100 times the free radical scavenging ability of other polyphenols which usually have 3 rings, sometimes 4. For example, green tea catechins have found recent popularity as an antioxidant. These substances only have 4 rings so are much less powerful. Seanol® is 40% fat-soluble, giving it a half-life of 10 to 12 hours, compared to 30 minutes for water-soluble, land-based polyphenols; therefore Seanol® is active in the body for extended periods of time.

Health Benefits Scientific evidence for chocolates benefits? Refs Scientific evidence for Seanol’s® benefits? Refs
Improvement In Sexual Function
No; but long understood to improve mood.
1, 2, 3, 4
Yes
5, 6
Beneficial Increase In Nitric Oxide
Yes
7
Yes
8
Reduction Of Cardiovascular Risk
Good indications of benefit of high cocoa content.
9, 10, 11, 12
Yes
13, 14, 15, 16
Making Blood Less Sticky
Yes
17
Yes
18, 19
Improves Weight
No
 
Yes
20, 21, 22
Improves Memory
Weak evidence.
23
Yes
24, 25, 26
Improved Brain Function
Weak evidence.
 
Yes
27
Anti Inflammatory
Yes
28
Yes
29, 30, 31
Protection From Seasonal Allergies
No
 
Yes
32, 33
Inhibition Of LDL Oxidation
Yes
34
Yes
35
Blood Pressure Improvement
Yes
36
Yes
37
Cholesterol Lowering
Yes
38
Yes
39
Peroxynitrite Scavenging
No
 
Yes
40
Protection From High Glucose
Yes
41
Yes
42
High ORAC Rating & Length of activity
Yes
30-40 minutes.
43
Yes
10-12 hours.
44
Safe To Consume
Yes
 
Yes
 

From hard bodies to hard core science, dark chocolate and Seanol®, have collected substantive support for their physiological and psychological effects.

For more information on Seanol® please read the article Ecklonia Cava Extract: Superior Polyphenol and Super-Antioxidant for Our Time by Richard Bierman LAc, REA.

But, whilst many products ‘claim’ to aid sexual function, only Seanol® has undergone a human trial that demonstrated a remarkable improvement in orgasmic function and intercourse satisfaction in adition to improving erectile function. Equalling or exceeding those benefits achieved by Viagra®.

Chocolate and Seanol® share many of the same benefits, based around their antioxidant properties, making this a unique organoleptic synergism. Seanol® is many times stronger than the effective elements found in dark chocolate, making our luxurious combination a chococeutical rather than a confection. The effects are achieved by ingesting 1-2 or more truffles per day.

One final thought – the phenyl ethylamine (PEA)45 in chocolate releases the same hormone as does sexual intercourse. Although contrarians object that the amount of PEA in chocolate is too small to produce significant results, this sweet drug also offers doses of the feel good hormone serotonin and caffeine along with its surge of PEA. A more recent UK study exploring these chemicals also found that chocolate produced a longer buzz than kissing.46

Safety

There are no known side effects to consuming Seanol®, it has been defined as a safe food and tens of thousands of humans have consumed it with no adverse effects, in fact the toxicity studies run so far can find no known toxic level despite massive ingestion of the product.

1 Tomaso, E.d., M. Beltramo, and D. Piomelli. 1996. Brain cannabinoids in chocolate. Nature 382 (Aug. 22):677.

2 Marzo, V.D, Piomelli, D. 1994. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372 (Dec. 15):686.

3 Zurer, P. 1996. Chocolate may mimic marijuana in brain. Chemical and Engineering News 74(Sept. 2):31

4 Salonia A, Fabbri F, et al. Chocolate and women's sexual health: An intriguing correlationJ Sex Med. 2006 May;3 (3):476-82.

5 Kang K, Park Y, Hwang HJ, Kim SH, Lee JG, Shin HC. Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors. Arch Pharm Res. 2003 Apr;26(4):286-93.

6 Hamed EA, Meki AR, Gaafar AA, Hamed SA. Role of some vasoactive mediators in patients with erectile dysfunction: their relationship with angiotensin-converting enzyme and growth hormone.Int J Impot Res. 2003 Dec;15(6):418-25.

7 Heiss, C; Dejam, A; Kleinbongard, P; Schewe, T; Sies, H; Kelm, M. Vascular effects of cocoa rich in flavan-3-ols. JAMA. 2003;290:1030–1031. doi: 10.1001/jama.290.8.1030.

8 Kang, K., Park, Y., Hwang, H. J., Kim, S. H., Lee, J. G., Shin, H.-C. (2003). Antioxidative Properties Of Brown Algae Polyphenolics And Their Perspectives As Chemopreventive Agents Against Vascular Risk Factors. Arch. Pharm. Res.. 26: 286-293

9 Knekt P, Jarvinen R, Reunanen A, Maatela J. Flavonoid intake and coronary mortality in Finland: a cohort study. Brit Med J 1996;312:478-81.

10 Hertog M, Kromhout D, Aravanis C, et al. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993;342:1007-11.

11 Hollman PC, Hertog MGL, Katan MB. Role of dietary flavonoids in protection against cancer and coronary heart disease. Biochem Soc Transact 1996;24:785-9.

12 Ding EL, Hutfless SM, Ding X, Girotra S. Chocolate and prevention of cardiovascular disease: a systematic review. Nutr Metab (Lond). 2006 Jan 3;3:2.

13 Fukuyama Y, Kodama M, Miura I, Kinzyo Z, Mori H, Nakayama Y, Takahashi M. Anti-plasmin inhibitor. V. Structures of novel dimeric eckols isolated from the brown alga Ecklonia kurome OKAMURA.Chem Pharm Bull (Tokyo). 1989 Sep;37(9):2438-40.

14 Shibata, Toshiyuki; Fujimoto, Ken; Nagayama, Kohki; Yamaguchi, Kuniko; Nakamura, Takashi. Inhibitory activity of brown algal phlorotannins against hyaluronidase. International Journal of Food Science & Technology, Volume 37, Number 6, August 2002 , pp. 703-709(7)

15 Shibata, T., Nagayama, K., Tanaka, R., Yamaguchi, K., Nakamura, T. Inhibitory Effects Of Brown Algal Phlorotannins On Secretory Phospholipase A2S, Lipoxygenases And Cycloxygenases. J. Appl. Phycol. 15: 61-66 (2003)

16 Kang, K., Park, Y., Hwang, H. J., Kim, S. H., Lee, J. G., Shin, H.-C. (2003). Antioxidative Properties Of Brown Algae Polyphenolics And Their Perspectives As Chemopreventive Agents Against Vascular Risk Factors. Arch. Pharm. Res.. 26: 286-293

17 Rein, D; Paglieroni, TG; Pearson, DA; Wun, T; Schmitz, HH; Gosselin, R; Keen, CL. Cocoa and wine polyphenols modulate platelet activation and function. J Nutr. 2000;130:2120S–6S

18 Fukuyama Y, Kodama M, Miura I, Kinzyo Z, Mori H, Nakayama Y, Takahashi M. Anti-plasmin inhibitor. VI. Structure of phlorofucofuroeckol A, a novel phlorotannin with both dibenzo-1,4-dioxin and dibenzofuran elements, from Ecklonia kurome Okamura. Chem Pharm Bull (Tokyo). 1990 Jan;38(1):133-5.

19 Fukuyama, Y., Kodama, M., Miura, I., Kinzyo, Z., Kido, M., Mori, H., Nakayama, Y., Takahashi, M. Structure Of An Anti-Plasmin Inhibitor, Eckol, Isolated From The Brown Alga Ecklonia Kurome Okamura And Inhibitory Activities Of Its Derivatives On Plasmin Inhibitors. Chem. Pharm. Bull. 37: 349-353 (1989)

20 Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV Jr. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000 May;25(1):87-90

21 Shin,HC. Seanol – Obesity/DGAT Research Notes, Live Chem Inc, Seoul, Korea, 2005

22 United States patent application20050101660 May 12th 2005, (Assigned To Haengwoo Lee).

23 Effects Of Chocolate Consumption On Enhancing Cognitive Performance. Bryan Raudenbush, presented Wheeling Jesuit University. Student Research and Scholarship Symposium. April 3, 2007

24 Lee, B.H., Stein, S. Improvement Of Learning Behavior Of Mice By An Antiacetylcholinesterase And Neuroprotective Agent Nx42, A Laminariales-Alga Extract. Presented To The Pharm. Soc. Kor., Spring Conference (2004); Manuscript Submitted To Korean Journal Of Food Science And Technology

25 Myung CS, Shin HC, Bao HY, Yeo SJ, Lee BH, Kang JS. Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase. Arch Pharm Res. 2005 Jun;28(6):691-8.

26 Composition For Prevention And Improvement Of Dementia And Promotion Of Memory, And Healthy Assistance Foodstuffs Containing The Composition” Korean Patent Application# 10-2003-88177 (Assigned To Haengwoo Lee).

27 Lee, B. (Hanbay National University)Unpublished research findings. Visiting Scholar. National Institute of Aging. National Institute of Health 2004

28 Schewe, T; Sadik, C; Klotz, LO; Yoshimoto, T; Kuhn, H; Sies, H. Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase. Biol Chem. 2001;382:1687–1696. doi: 10.1515/BC.2001.204.

29 Shin HC, Hwang HJ, Kang KJ, Lee BH. An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava. Arch Pharm Res. 2006 Feb;29(2):165-71

30 Kang, K.J., Hwang, H.J., Hong, D.H., Park, Y.J., Kim, S,H., Lee, B.H., Shin, H.C. Anti-Oxidant And Anti-Inflammatory Activities Of Ventol, A Phlorotannin-Rich Natural Agent Derived From Ecklonia Cava, And Its Effect On Proteoglycan Degradation In Cartilage Explant Culture.  Submitted To Molecular Pathology And Pharmacology

31 Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG, Jeon YJ, Kim SK. Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity. Life Sci. 2006 Sep 5;79(15):1436-43. Epub 2006 May 7

32 Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Lee Y, Kim SY, Kim HS, Joo HG, Park JW, Ham YM, Lee NH, Hyun JW. Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. FEBS Lett. 2005 Nov 21;579(28):6295-304. Epub 2005 Oct 19

33 Kang KA, Lee KH, Chae S, Koh YS, Yoo BS, Kim JH, Ham YM, Baik JS, Lee NH, Hyun JW. Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage. Free Radic Res. 2005 Aug;39(8):883-92.

34 Kondo, K; Hirano, R; Matsumoto, A; Igarashi, O; Itakura, H. Inhibition of LDL oxidation by cocoa. Lancet. 1996;348:1514. doi: 10.1016/S0140-6736(05)65927-2.

35 Shin HC, Hwang HJ, Kang KJ, Lee BH. An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava. Arch Pharm Res. 2006 Feb;29(2):165-71

36 Engler MB, Engler MM, et al. Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr. 2004 Jun;23(3):197-204

37 Jang, Y. Effect of Mo’bar on hemopoiesis, endothelial function, endocrinological profile,and daily activity n adults.Cardiology Division, College of Medicine, Yonsei University.

38 Fraga, CG; Actis-Goretta, L; Ottaviani, JI; Carrasquedo, F; Lotito, SB; Lazarus, S; Schmitz, HH; Keen, CL. Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players. Clin Dev Immunol. 2005;12:11–17.

39 Jang, Y. Effect of Mo’bar on hemopoiesis, endothelial function, endocrinological profile,and daily activity n adults.Cardiology Division, College of Medicine, Yonsei University.

40 Nakamura, T., Nagayama, K., Uchida, K., Tanaka, R. Antioxidant Activity Of Phlorotannins Isolated From The Brown Alga Eisenia Bicyclis. Fisheries Sci. 62: 923-926 (1996).

41 Grassi, D; Lippi, C; Necozione, S; Desideri, G; Ferri, C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr. 2005;81:611–614.

42 In Vitro Study, Upublished. LiveChem Inc.

43. Lee, KW; Kim, YJ; Lee, HJ; Lee, CY. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem. 2003;51:7292–7295. doi: 10.1021/jf0344385.

44 Athukorala Y, Kim KN, Jeon YJ. Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem Toxicol. 2006 Jul;44(7):1065-74. Epub 2006 Mar 3

45 Ziegleder G, Stojacic E, Stumpf B. Occurrence of beta-phenylethylamine and its
derivatives in cocoa and cocoa products. Z Lebensm Unters Forsch 1992 Sep; 195(3):235-8

46 http://news.bbc.co.uk/2/hi/health/6558775.stm